New prognostic marker for breast cancer

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Elevated levels of GLI1 (glioma-associated oncogene homolog 1) protein in human breast cancer are linked to unfavorable prognosis and progressive stages of disease. Scientists writing in the open access journal BMC Cancer found increased expression of GLI1 in samples taken from more advanced and less survivable tumors.

Edgar Dahl led a team of scientists from RWTH Aachen's University Hospital who sought to evaluate whether GLI1 could represent a new prognostic marker in breast cancer therapy. He said, "GLI1, a mediator of the so-called 'hedgehog' signaling pathway, has previously been implicated in the development of different human tumor entities. We've found a positive, significant association between overexpression of GLI1 and unfavorable overall survival outcome in human breast cancer. This association has not been reported anywhere else so far, but similar tendencies were recently shown in human esophageal cancer".

The scientists studied samples of 229 invasive breast carcinomas taken from patients at the hospital, along with samples of normal human breast tissue for comparison. As well as poor survival, overexpression of the GLI1 protein was linked to tumor stage and lymph node status of the breast tumors analyzed. Dahl said, "Taken together, these results support a role of GLI1 as a new prognostic biomarker in breast cancer. Future studies will determine whether GLI1 can be successfully included into multimarker panels for early cancer detection or molecular sub-typing of breast cancer. This could support personalized breast cancer medicine".


Posted by: Janet    Source