June 25, 2009, 6:01 PM CT
More gene mutations linked to autism risk

More pieces in the complex autism inheritance puzzle are emerging in the latest study from a research team including geneticists from The Children's Hospital of Philadelphia, the University of Pennsylvania School of Medicine and several collaborating institutions. This study identified 27 different genetic regions where rare copy number variations missing or extra copies of DNA segments were found in the genes of children with autism spectrum disorders (ASDs), but not in the healthy controls. The complex combination of multiple genetic duplications and deletions is thought to interfere with gene function, which can disrupt the production of proteins necessary for normal neurological development.
"We focused on changes in the exons of DNAprotein-coding areas in which deletions or duplications are more likely to directly disrupt biological functions," said study leader Hakon Hakonarson, M.D., Ph.D., director of the Center for Applied Genomics at The Children's Hospital of Philadelphia and associate professor of Pediatrics at the University of Pennsylvania School of Medicine. "We identified additional autism susceptibility genes, a number of of which, as we previously found, belong to the neuronal cell adhesion molecule family involved in the development of brain circuitry in early childhood." He added that the team discovered a number of "private" gene mutations, those found only in one or a few individuals or familiesan indication of genetic complexity, in which a number of different gene changes may contribute to an autism spectrum disorder.........
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May 20, 2009, 7:39 PM CT
Mother-infant psychotherapy
Psychotherapists who treat mothers suffering from postpartum depression and other mood disorders with their infants have developed a proven process that contributes to a greater positive experience with immediate insights for the mothers to develop healthy connections between their maternal experiences and their infants' behaviors.
Given the documented detrimental effects of postpartum depression on infants and the mother-infant relationship, mental health professionals concerned with child development and families are anxious to understand models of best practices in order to prevent untoward outcomes.
In a focus group study to evaluate the effectiveness of an agency-based mother-infant therapy program, nine therapists, each with 20 + years experience working with parents and babies, talked about their practices. A Boston University School of Social Work-led research team asked the participants to summarize their work, then describe what makes for therapeutic change in mother-infant treatment and how they know when it's effective. Their findings "Mother-Infant Psychotherapy: Examining the Therapeutic Process of Change," were just published in
Infant Mental Health JournalThe therapists -- a multidisciplinary group of three psychology experts, four social workers, one psychiatry expert and an educator -- elaborated on how they helped depressed mothers tune in to the nuances of what their babies were telling them and communicated how best to respond. The clinicians are part of the Jewish Family and Children's Service Early Connections program, a home-based mother-infant psychotherapy intervention that specializes in the therapy of postpartum depression (PPD) and mood disorders. The program's key goal is to increase the mother's ability to be affectively present in her interaction with the child and to address issues that arise as result of becoming a mother.........
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May 11, 2009, 5:03 AM CT
Does mom know when it is enough?
As the childhood obesity epidemic in the United States continues, scientists are examining whether early parent and child behaviors contribute to the problem. A study from the Department of Nutritional Sciences, Rutgers University, reported in the May/June 2009 issue of the
Journal of Nutrition Education and Behavior reports that mothers who miss signs of satiety in their infants tend to overfeed them, leading to excess weight gains during the 6 month to 1 year period.
Ninety-six low-income black and Hispanic mothers, who chose to formula feed exclusively, were enrolled in the study. Data was collected during an initial interview and three home visits at 3, 6, and 12 months. During the home visits, feedings were observed, the mothers were interviewed, and the child's weight was measured. Feeding diaries were also checked for omissions or clarifications.
Many characteristics that predicted infant weight gain from birth to 3 months were included in the analysis. These were birth weight, gender, race/ethnicity, maternal age, education, country of origin, body mass index (BMI) before pregnancy, and weight gain during pregnancy. For the 3 to 6 month period, birth weight, maternal BMI, infant weight gain from birth to 3 months, infant length gain from birth to 3 months, the estimated number of feeds per day, the month that solid food was introduced, and the mothers' sensitivity to the infants' signals at 3 months were included. And, finally, for the 6 to 12 month period, birth weight, maternal BMI, infant weight gain from 3 to 6 months, infant length gain from 3 to 6 months, maternal sensitivity to infant signals at 6 months, and the estimated number of feeds/day at 6 months were entered as the independent variables.........
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May 5, 2009, 5:22 AM CT
Iron deficiency in womb and brain maturation
Iron plays a large role in brain development in the womb, and new University of Rochester Medical Center research shows an iron deficiency may delay the development of auditory nervous system in preemies. This delay could affect babies ability to process sound which is critical for later language development in early childhood.
The study reviewed 80 infants over 18 months, testing their cord blood for iron levels and using a non-invasive tool -- auditory brainstem-evoked response (ABR) -- to measure the maturity of the brain's auditory nervous system soon after birth. The study observed that the brains of infants with low iron levels in their cord blood had abnormal maturation of auditory system in comparison to infants with normal cord iron levels.
"Sound isn't transmitted as well through the immature auditory pathway in the brains of premature babies who are deficient in iron as in comparison to premature babies who have enough iron," said Sanjiv Amin, M.D., associate professor of Pediatrics at the University of Rochester Medical Center and author of the abstract presented today at the Pediatric Academic Society meeting in Baltimore. "We suspect that if the auditory neural system is affected during developmental phase, then other parts of the brain could also be affected in the presence of iron deficiency".........
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May 5, 2009, 5:11 AM CT
Possible and actual autism diagnosis
"Timely identification and diagnosis of an autism spectrum disorder (ASD) can impact a child's development and is the key to opening the door to the services and therapies available to children with autism," says Paul Shattuck, Ph.D., assistant professor at the George Warren Brown School of Social Work at Washington University in St. Louis. "Unfortunately, our research shows that the average age of autism diagnosis is nearly six years old, which is three to four years after diagnosis is possible".
Shattuck is the main author of an article on the timing of ASD identification in the current issue of the Journal of the American Academy of Child and Adolescent Psychiatry.
He and co-author of studys used data from 13 sites around the country that were funded by the Centers for Disease Control and Prevention (CDC) to collect information from the health and education records of eight year olds with a wide variety of developmental problems in 2002.
Shattuck's research observed that females were identified later than males and that early diagnosis was commonly associated with a more severe or obvious cognitive impairment. There were no disparities in the age of diagnosis by race when the data are pooled from all 13 sites. However, in further analyses reported elsewhere, Shattuck and his colleagues have observed that Black and Hispanic children who meet diagnostic criteria for autism are much less likely to actually have a documented diagnosis in their records.........
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May 4, 2009, 5:12 AM CT
Furniture tip-over injuries rising
Eventhough most parents do not consider furniture and televisions to be dangerous, children are often injured when these items tip over. A recent study conducted by the Center for Injury Research and Policy of The Research Institute at Nationwide Children's Hospital observed that from 1990-2007 an average of nearly 15,000 children younger than 18 years of age visited emergency departments annually for injuries received from furniture tip-overs.
As per the study, reported in the online issue of
Clinical Pediatrics in May, most furniture tip-over-related injuries occurred among children younger than 7 years of age and resulted from televisions tipping over. More than one quarter of the injuries occurred when children pulled over or climbed on furniture. Children ages 10-17 years were more likely to suffer injuries from desks, cabinets or bookshelves tipping over. Head and neck injuries were most common among younger children, while children older than 9 years were more likely to suffer injuries to the lower body.
Despite warnings from the U.S. Consumer Product Safety Commission, the number of injuries involving televisions and other furniture tipping over onto children has increased in this country since the early part of 1990s.
"There was a more than 40 percent increase in the number of injuries during the study period, and the injury rate also significantly increased during these years," said study senior author Gary Smith, MD, DrPH, director of the Center for Injury Research and Policy at Nationwide Children's Hospital. "This trend demonstrates the inadequacy of current prevention strategies and underscores the need for increased prevention efforts".........
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May 1, 2009, 5:06 AM CT
Maternal depression and sleep disturbance in infants
A study in the May 1 issue of the journal
SLEEP suggests that babies born to mothers with depression are more likely to suffer from significant sleep disturbances at 2 weeks postpartum that continue until 6 months of age. Findings of the study are of particular importance, as sleep disturbances in infancy may result in increased risk for developing early-onset depression in childhood.
Results indicate that infants born to mothers with depression had significant sleep disturbances in comparison to low-risk infants; the high-risk group had an hour longer nocturnal sleep latency, shorter sleep episodes and lower sleep efficiency than infants who were born to mothers without depression. Eventhough average sleep time in a 24 hours did not differ by risk group at eight two or four weeks, nocturnal total sleep time was 97 minutes longer in the low-risk group at both recording periods. High-risk infants also had significantly more daytime sleep episodes of a shorter average duration.
Prior studies have observed that levels of cortisol, a hormone that is linked to stress, is increased during pregnancy and after delivery in depressed mothers, indicating that the mother's hormone level may affect the infant's sleep.
As per the main author, Roseanne Armitage, PhD, director of the Sleep and Chronophysiology Laboratory at the University Of Michigan Depression Center, while maternal depression does have a negative effect on infants' sleep, the damage appears to be reversible.........
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April 29, 2009, 5:23 AM CT
New gene variant for autism
UCLA scientists, in partnership with 30 research institutions across the country, have identified a new gene variant that is highly common in autistic children. And when scientists scrutinized the activity of the gene, known as CDH10, in the fetal brain, they discovered that it is most active in key regions that support language, speech and interpreting social behavior.
Published April 28 in the advance online edition of the journal
Nature, the two findings suggest that CDH10 plays a critical role in shaping the developing brain and may contribute to a prenatal risk of autism.
A variant is a gene that has undergone subtle changes from the normal DNA yet is shared by a significant portion of the population.
"While this gene variant is common in the general population, we discovered that it occurs about 20 percent more often in children with autism," said study author Dr. Daniel Geschwind, director of the UCLA Center for Autism Treatment and Research. "A major change like this in the genetic code is too common to be a simple mutation it is a risk factor in the origin of the disease."
Using the largest population sample to date, the researchers systematically scanned the DNA of 3,100 individuals from 780 families nationwide. Each family had at least two autistic children.........
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April 28, 2009, 5:17 AM CT
Psychological effects of inadequate sleep
A recent Finnish study suggests that children's short sleep duration even without sleeping difficulties increases the risk for behavioral symptoms of ADHD.
During the recent decades, sleep duration has decreased in a number of countries; in the United States a third of children are estimated to suffer from inadequate sleep. It has been hypothesised that sleep deprivation may manifest in children as behavioral symptoms rather than as tiredness, but only few studies have investigated this hypothesis.
The scientists at the University of Helsinki and National Institute of Health and Welfare, Finland, examined whether decreased sleep leads to behavioral problems similar to those exhibited by children with attention-deficit/hyperactivity disorder (ADHD).
280 healthy children (146 girls and 134 boys) took part in the study.
The scientists tracked the children's sleep using parental reporting as well as actigraphs, or devices worn on the wrist to monitor sleep.
The children whose average sleep duration as measured by actigraphs was shorter than 7.7 hours had a higher hyperactivity and impulsivity score and a higher ADHD total score, but similar inattention score than those sleeping for a longer time. In multivariate statistical models, short sleep duration remained a statistically significant predictor of hyperactivity and impulsivity, and sleeping difficulties were linked to hyperactivity, impulsivity and inattention. There were no significant interactions between short sleep and sleeping difficulties.........
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April 15, 2009, 5:10 AM CT
Melatonin for sleep problems in children with autism
Westchester, Ill. - A study in the April 15 issue of the
Journal of Clinical Sleep Medicine determined that over-the-counter melatonin medicine can shorted the length of time it takes for children with autistic spectrum disorder (ASD), Fragile X Syndrome (FXS), or both to fall asleep at the beginning of the night.
Results of the study indicated that children who received over-the-counter melatonin therapys experienced significant improvements in total night sleep durations, sleep latency times, and sleep-onset times. Mean sleep duration was longer on melatonin than placebo by 21 minutes, sleep-onset latency was shorter by 28 minutes and sleep-onset time was earlier by 42 minutes.
As per the senior author, Beth L. Goodlin-Jones, PhD of the M.I.N.D Institute at the University of California Davis Health System in Sacramento, Calif., therapy with over-the-counter melatonin supplements benefits children of all ages, which helps alleviate some of the additional stress that parents of special-needs children experience.
"Sleep onset problems at the beginning of the night are very troublesome for children and their families," said Goodlin-Jones. "Sometimes children may take one to two hours to fall asleep and often they disrupt the household during this time."........
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April 8, 2009, 5:09 AM CT
Digital album to take care of kids' health
Modern moms and dads snap thousands of photos, recording every drooling smile and flailing attempt to crawl. Until now, this frenzy of activity could be one more thing distracting parents from monitoring their child's health and developmental progress.
Now Julie Kientz at the University of Washington has built a high-tech tool that takes photos and video, creates an online diary and family newsletters, and at the same time tracks a child's developmental milestones. The multimedia system, called Baby Steps, combines sentimental snapping with medical record-keeping. Baby Steps feels like a fun toy for parents, but scientists found in a small pilot study that having it on their home computers doubled the parents' collection of medically relevant information.
Kientz, an assistant professor of human-centered design and engineering and the Information School, presents the results this week in Boston at the Conference on Human Factors in Computing Systems. Co-authors are Rosa Arriaga and Gregory Abowd of the Georgia Institute of Technology.
Most parents can tell you the first time their baby smiled, or took his or her first step. But what about the first time a baby could adjust his or her gaze to look in the direction of a pointed finger, which an inability to do at a certain age indicates a possible risk of autism?.........
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April 2, 2009, 5:11 AM CT
A sweeping new theory for autism
Researchers at Albert Einstein College of Medicine of Yeshiva University have proposed a sweeping new theory of autism that suggests that the brains of people with autism are structurally normal but dysregulated, meaning symptoms of the disorder might be reversible.
The central tenet of the theory, reported in the recent issue of
Brain Research Reviews, is that autism is a developmental disorder caused by impaired regulation of the locus coeruleus, a bundle of neurons in the brain stem that processes sensory signals from all areas of the body.
The new theory stems from decades of anecdotal observations that some autistic children seem to improve when they have a fever, only to regress when the fever ebbs. A 2007 study in the journal Pediatrics took a more rigorous look at fever and autism, observing autistic children during and after fever episodes and comparing their behavior with autistic children who didn't have fevers. This study documented that autistic children experience behavior changes during fever.
"On a positive note, we are talking about a brain region that is not irrevocably altered. It gives us hope that, with novel therapies, we will eventually be able to help people with autism," says theory co-author Mark F. Mehler, M.D., chairman of neurology and director of the Institute for Brain Disorders and Neural Regeneration at Einstein.........
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April 2, 2009, 4:56 AM CT
Autism stress hormone level Link
Some of the symptoms of the autistic condition Asperger Syndrome, such as a need for routine and resistance to change, could be associated with levels of the stress hormone cortisol, suggests new research led by the University of Bath.
Normally, people have a surge of this hormone shortly after waking, with levels gradually decreasing throughout the day. It is thought this surge makes the brain alert, preparing the body for the day and helping the person to be aware of changes happening around them.
However, a study led by Dr Mark Brosnan and Dr Julie Turner-Cobb from the Department of Psychology at the University of Bath, and Dr David Jessop from the University of Bristol, has observed that children with Asperger Syndrome (AS) do not experience this surge.
The scientists believe these findings may help to explain why individuals with this condition have difficulties with minor changes to their routine or changes in their environment.
The study has been reported in the peer-evaluated journal
PsychoneuroendocrinologyDr Brosnan explained: "Cortisol is one of a family of stress hormones that acts like a 'red alert' that is triggered by stressful situations allowing a person to react quickly to changes around them.
"In most people, there is a two hundred percent increase in levels of this hormone within 30 minutes of waking up, with levels gradually declining during the day as part of the internal body clock.........
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March 31, 2009, 5:30 AM CT
Is time of conception linked to birth defects?
A study reported in the April 2009 issue of the medical journal
Acta Pdiatrica is the first to report that birth defect rates in the United States were highest for women conceiving in the spring and summer. The scientists also observed that this period of increase risk correlated with increased levels of pesticides in surface water across the United States.
Studying all 30.1 million births which occurred in the U.S. between 1996 and 2002, the scientists found a strong association between the increased number of birth defects in children of women whose last menstrual period occurred in April, May, June or July and elevated levels of nitrates, atrazine and other pesticides in surface water during the same months. While a number of of these chemicals, including the herbicide atrazine which is banned in European countries but permitted in the U.S., are suspected to be harmful to the developing embryo, this is the first study to link their increased seasonal concentration in surface water with the peak in birth defects in infants conceived in the same months.
The connection between the month of last menstrual period and higher rates of birth defects was statistically significant for half of the 22 categories of birth defects reported in a Centers for Disease Control database from 1996 to 2002 including spina bifida, cleft lip, clubfoot and Down's syndrome.........
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March 30, 2009, 5:28 AM CT
How autism skews developing brain?
Individuals with autism spectrum disorders (ASD) tend to stare at people's mouths rather than their eyes. Now, an NIH-funded study in 2-year-olds with the social deficit disorder suggests why they might find mouths so attractive: lip-syncthe exact match of lip motion and speech sound. Such audiovisual synchrony preoccupied toddlers who have autism, while their unaffected peers focused on socially meaningful movements of the human body, such as gestures and facial expressions.
"Typically developing children pay special attention to human movement from very early in life, within days of being born. But in children with autism, even as old as two years, we saw no evidence of this," explained Ami Klin, Ph.D., of the Yale Child Study Center, who led the research. "Toddlers with autism are missing rich social information imparted by these cues, and this is likely to adversely affect the course of their development."
Klin, Warren Jones, Ph.D., and his colleagues at Yale, report the findings of their study, funded in part by the National Institute of Health's National Institute of Mental Health, online March 29, 2009 in the journal
NatureFor the first time, this study has pinpointed what grabs the attention of toddlers with ASDs," said NIMH Director Thomas R. Insel, M.D. "In addition to potential uses in screening for early diagnosis, this line of research holds promise for development of new therapies based on redirecting visual attention in children with these disorders."........
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March 30, 2009, 5:05 AM CT
Infant weight gain linked to childhood obesity
As childhood obesity continues its thirty-year advance from occasional curiosity to cultural epidemic, health care providers are struggling to find out whyand the reasons are a number of. Increasingly sedentary environments for both adults and children, as well as cheap and ubiquitous processed foods no doubt play a role, but scientists are finding more evidence that the first clues for childhood obesity appears to begin as far back as early infancy.
A newly released study led by scientists in the Department of Ambulatory Care and Prevention at Harvard Medical School and Harvard Pilgrim Health Care, as well as Children's Hospital Boston, has observed that rapid weight gain during the first six months of life may place a child at risk for obesity by age 3.
"There is increasing evidence that rapid changes in weight during infancy increase children's risk of later obesity," says main author Elsie Taveras, assistant professor in the HMS Department of Ambulatory Care and Prevention and co-director of the One Step Ahead clinic, a pediatric overweight prevention program at Children's Hospital Boston. "The mounting evidence suggests that infancy appears to be a critical period during which to prevent childhood obesity and its related consequences."
These findings are reported in the April edition of the journal
Pediatrics........
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March 19, 2009, 5:19 AM CT
Longer bouts of exercise to prevent childhood obesity
Kinesiology and Health Studies professor Ian Janssen
Photo by Stephen Wild
Children who exercise in bouts of activity lasting five minutes or longer are less likely to become obese than those whose activity levels are more sporadic and typically last less than five minutes each, Queen's University scientists have discovered.
Led by Kinesiology and Health Studies professor Ian Janssen, the newly released study supports Canada's Physical Activity Guidelines for Children and Youth, which call for children to accumulate at least 90 minutes of moderate-to-vigorous physical activity over the course of the day, in bouts of at least five to 10 minutes' duration. Until now there has been no scientific evidence to support the recommendation of sustained, rather than sporadic exercise.
"Even in 60-minute physical education classes or team practices, children are inactive for a large portion of the time and this would not necessarily count as sustained exercise," says Dr. Janssen. "When children engage in longer periods of sustained physical activity, there is a smaller likelihood that they will be overweight or obese." .
The findings are reported in the recent issue of the American Journal of Preventive Medicine.
Conducted by Dr. Janssen and graduate student Amy Mark, the study analyzed data from 2,498 youth aged eight to 17, who participated in the National Health and Nutrition Examination Survey. Sporadic (one to four minutes), short (five to nine minutes) and medium-to-long (10 minutes and longer) bouts of moderate-to-vigorous physical activity were measured using motion sensors. Participants' body mass index (BMI) was used to classify them as normal weight or obese.........
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March 12, 2009, 0:24 AM CT
Learning difficulties for extremely premature children
Children born extremely prematurely are at high risk of developing learning difficulties by the time they reach the age of 11.
A study carried out by the University of Warwick, in collaboration with University College London and the University of Nottingham, showed almost two thirds of children born extremely prematurely require additional support at school.
Extremely premature refers to children who are born below 26 weeks gestation.
Scientists looked at 307 extremely preterm children born in the UK and Ireland in 1995. 219 were re-assessed at 11 years of age and in comparison to 153 classmates born at term.
The scientists found extremely preterm children had significantly lower reading and maths scores than classmates. Also extremely preterm boys were more likely to have more serious impairments than girls.
This study, published recently (10) in the
Archives of Disease in Childhood Fetal Neonatal Edition , is the latest report from the EPICure study group. This group has produced two prior papers examining the children at aged two and a half and six years old.
Overall, just under half of the extremely premature children have serious disabilities, such as learning difficulties, cerebral palsy and impaired vision or hearing.........
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March 5, 2009, 6:13 AM CT
Childhood obsessive symptoms and OCD
A research group led Miguel ngel Fullana, researcher at the Universitat Autnoma de Barcelona Department of Psychiatry and Legal Medicine, psychology expert the Institute of Psychiatric Treatment of Hospital de Mar in Barcelona and researcher at King's College Institute of Psychiatry, London, has carried out a first study which connects the symptoms of obsessive-compulsive rituals in childhood with the risk of developing an obsessive-compulsive disorder as adults. One of the main conclusions of the study is that children who repeatedly manifest having obsessions and compulsions notably increase their risk of suffering from a disorder during the later part of life.
The research used data from the Dunedin Study which has been carried out with citizens of Dunedin, New Zealand since 1973. It is the only place in the world where a long-term follow-up of different psychological variables has taken place from childhood to adulthood with a sample of one thousand people. Scientists assessed the evolution of two variables in participants at ages 11, 26 and 32: the repeated presence of obsessive ideas (e.g. recurrent and undesired thoughts to harm others) and compulsive rituals (a need to wash their hands constantly, to check up on small everyday tasks to prevent harm or repeatedly carrying out activities that seem meaningless, etc.).........
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March 3, 2009, 6:13 AM CT
TV viewing before the age of 2
A longitudinal study of infants from birth to age 3 showed TV viewing before the age of 2 does not improve a child's language and visual motor skills, as per research conducted at Children's Hospital Boston and Harvard Medical School. The findings, reported in the recent issue of
Pediatrics, reaffirm current guidelines from the American Academy of Pediatrics (AAP) that recommend no television under the age of 2, and suggest that maternal, child, and household characteristics are more influential in a child's cognitive development.
"Contrary to marketing claims and some parents' perception that television viewing is beneficial to children's brain development, no evidence of such benefit was found," says Marie Evans Schmidt, PhD, main author of the study.
The study analyzed data of 872 children from Project Viva, a prospective cohort study of mothers and their children. In-person visits with both mothers and infants were performed immediately after birth, at 6 months, and 3 years of age while mothers completed mail-in questionnaires regarding their child's TV viewing habits when they were 1 and 2 years old. It was conducted by scientists in the Center on Media and Child Health at Children's and the Department of Ambulatory Care and Prevention at Harvard Medical School and Harvard Pilgrim Health Care.........
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February 20, 2009, 6:10 AM CT
Alleviating your child's fears of dental visit
For a number of children, a trip to the doctor or dentist is a stressful experience. The sensory environment (i.e., the sounds, smells, and lights linked to the clinical setting) can cause a child's anxiety levels to rise. This is particularly true in children with developmental disabilities who may have difficulty understanding the unfamiliar clinical environment. A newly released study soon to be published in
The Journal of Pediatrics explores the relationship between the sensory environment and anxiety levels in children.
Dr. Michele Shapiro of the Issie Shapiro Educational Center and his colleagues from Hebrew University in Israel studied the effects of the sensory environment on a child's anxiety levels during two separate routine cleaning visits to the dentist. The scientists observed 35 children between the ages of 6-11 years, 16 of whom were developmentally disabled. They measured the anxiety levels of the children during each visit using a behavior checklist and monitored each child's electro-dermal activity, an objective measure of arousal.
The first trip included the typical sensory experiences of a dental office, including fluorescent lighting and the use of an overhead dental lamp. During the second trip, however, the scientists created a sensory adapted environment that modified the experience of the children. No overhead lighting was used, a slow moving repetitive color lamp was added, and the dental hygienist wore a special LED headlamp that directed the light into the child's mouth. The children listened to soothing music and were wrapped in a heavy vest that created a "hugging" effect. The dental chair itself was also modified to produce a vibration.........
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