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Lung Cancer Blog: Compound Related To Vitamin A Fights Lung Cancer

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Jan 18, 2006

Compound Related To Vitamin A Fights Lung Cancer

Compound Related To Vitamin A Fights Lung Cancer
A compound, which is a relative of vitamin A may be the next weapon in the fight against lung cancer. New research shows promise of lung cancer tumor progression or slowing of the growth using this compound in mice.

This research was led by Dr. Ming You, director of the Chemoprevention Program at the Siteman Cancer Center at Washington University. Dr.You and his colleagues found that this compound, called bexarotene, is effective in prevention of lung cancer cells in mouse. They also found that this compound doesn't cause the severe skin irritations that have limited the use of other vitamin A derivatives in cancer therapies.

The ideal substance to prevent cancer would block tumor growth without causing unpleasant or dangerous side effects. In other studies, bexarotene showed some promise in cancer treatment. It extended survival in patients with non-small cell lung cancer, the most common type of lung cancer and one that has a five-year survival rate of less than 5 percent when diagnosed at the advanced stage.

In the current study, to be published in an upcoming issue of Oncogene, You, who is also professor of surgery, and Dr. Yian Wang, associate professor of surgery and their colleagues showed that lung-cancer-susceptible mice receiving non-toxic doses of bexarotene ended up with fewer and smaller benign and malignant tumors than mice that were not treated with bexarotene.

The researchers saw a reduction of almost 50 percent in terms of total amount of tumor in mice who were given bexarotene for 12 weeks after the animals had already developed benign tumors following injection of a lung carcinogen. Bexarotene also inhibited the progression of benign to malignant tumors by about 50 percent. The mice were engineered to have the genetic alterations seen in human lung cancers, so they readily develop lung cancer when given known lung carcinogens.

Scott      



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Do you read all of the blogs published by medicineworld.org? Many of our bloggers are busy keeping you updated on the various health related topics. We publish the following blogs at this time.

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Lung cancer blog: Lung cancer blog is managed by Scott with the help of other bloggers. Through this blog Scott and his friends constantly remind the readers about the dangers of smoking. It's a never-ending struggle against this miserable disease with which a social stigma of smoking is associated.

Colon cancer blog: Colon cancer blog is run by Sue and other bloggers. Sue brings a personal touch to the colon cancer blog since her mother died of colon cancer few years ago. She writes about stories, research news and advances in treatment related to colon cancer.

Prostate cancer blog: Prostate cancer is the most common cancer among American men. American Cancer Society estimates that over 230,000 new cases of prostate cancer occur in the United state every year. This important blog about prostate cancer is run by Mark and other bloggers. This blog brings news, stories, and other personal observations related to prostate cancer.

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Janet      


Lung cancer
We engage a never-ending daily struggle to understand and defeat the hidden mysteries of cancer. This is a long and laborious fight, but some moments stand out as grim reminders of the severity of the problem and ruthlessness of the enemy. We recently heard about the sad demise of Peter Jennings, who was the news anchor of ABC News for a long time.

Lung Cancer Blog: Compound Related To Vitamin A Fights Lung Cancer

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