Feb 27, 2006

Nexavar (Sorafenib) Tablets For Lung Cancer

Patients with non-small cell lung cancer may soon have an open trial using Nexavar (sorafenib) tablets in combination with chemotherapy. Bayer Pharmaceuticals Corporation and Onyx Pharmaceuticals, Inc today announced the initiation of a randomized, double-blind, placebo-controlled Phase III clinical trial studying Nexavar (sorafenib) tablets administered in combination with the chemotherapeutic agents carboplatin and paclitaxel in patients with non-small cell lung cancer (NSCLC).

This multicenter study will compare the effectiveness of Nexavar in combination with two chemotherapeutic agents namely carboplatin and paclitaxel. The control arm of the study would be just carboplatin and paclitaxel alone. Study co-coordinators are looking forward to enrolling approximately 900 patients. This study will assess overall survival as the primary endpoint. Secondary endpoints would include progression-free survival, tumor response and safety. The study participants may not have received prior systemic anticancer treatment. The study is open to all subtypes of NSCLC including those with squamous cell or adeno carcinomas. Patients in the study will be randomized to receive 400 mg of oral Nexavar twice daily or matching placebo, in addition to carboplatin and paclitaxel for six cycles. After completion of the chemotherapy phase patients will continue in a maintenance phase where Nexavar or placebo will be administered as a single agent. The study will be conducted at more than 130 sites in North America, South America, Europe and the Asia Pacific region.

It is to be noted that Nexavar (sorafenib) has been recently shown to be highly effective in the treatment of renal cell cancer and this drug has been FDA approved for the treatment of renal cell cancer.

Scott      

Do You Read All Of Our Cancer Blogs?

Do you read all of the blogs published by medicineworld.org? Many of our bloggers are busy keeping you updated on the various health related topics. We publish the following blogs at this time.

Cancer blog: I manage the cancer blog with lots of help and support form other bloggers. Through this cancer blog my friends and I try to bring stories of hope for patients with cancer. The cancer blog often republishes important blog posts from other cancer related blogs at Medicineworld.org. If you are searching for a blog that covers wide variety of cancer topics, this may be the one for you.

Breast cancer blog: Breast cancer blog is run by Emily and other bloggers and they bring you the latest stories, news and events that are related to breast cancer. Increasing awareness about breast cancer among women and in the general population is the main goal of this breast cancer blog.

Lung cancer blog: Lung cancer blog is managed by Scott with the help of other bloggers. Through this blog Scott and his friends constantly remind the readers about the dangers of smoking. It's a never-ending struggle against this miserable disease with which a social stigma of smoking is associated.

Colon cancer blog: Colon cancer blog is run by Sue and other bloggers. Sue brings a personal touch to the colon cancer blog since her mother died of colon cancer few years ago. She writes about stories, research news and advances in treatment related to colon cancer.

Prostate cancer blog: Prostate cancer is the most common cancer among American men. American Cancer Society estimates that over 230,000 new cases of prostate cancer occur in the United state every year. This important blog about prostate cancer is run by Mark and other bloggers. This blog brings news, stories, and other personal observations related to prostate cancer.

Medicineworld.org publishes a diabetes watch blog and this blog is run by JoAnn other bloggers. This diabetes watch blog brings you the latest in the field of diabetes. This includes personal stories, advances in diagnosis and treatment, and other observations about diabetes. Improving awareness about diabetes is an important mission of this group.

Janet      

Lung cancer
We engage a never-ending daily struggle to understand and defeat the hidden mysteries of cancer. This is a long and laborious fight, but some moments stand out as grim reminders of the severity of the problem and ruthlessness of the enemy. We recently heard about the sad demise of Peter Jennings, who was the news anchor of ABC News for a long time.