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Colon Cancer Blog :from Medicineworld.org

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This page you have reached is an archive page of colon cancer blog. If you wish to read current posting of this blog, please go to colon cancer blog main page. If you wish to read the archived blog postings, simply scroll down to the lower part of the page.

Do you read all of the blogs published by medicineworld.org? Many of our bloggers are busy keeping you updated on the various health related topics. We publish the following blogs at this time.

Cancer blog: I manage the cancer blog with lots of help and support form other bloggers. Through this cancer blog my friends and I try to bring stories of hope for patients with cancer. The cancer blog often republishes important blog posts from other cancer related blogs at Medicineworld.org. If you are searching for a blog that covers wide variety of cancer topics, this may be the one for you.

Breast cancer blog: Breast cancer blog is run by Emily and other bloggers and they bring you the latest stories, news and events that are related to breast cancer. Increasing awareness about breast cancer among women and in the general population is the main goal of this breast cancer blog.

Lung cancer blog: Lung cancer blog is managed by Scott with the help of other bloggers. Through this blog Scott and his friends constantly remind the readers about the dangers of smoking. It's a never-ending struggle against this miserable disease with which a social stigma of smoking is associated.

Colon cancer blog: Colon cancer blog is run by Sue and other bloggers. Sue brings a personal touch to the colon cancer blog since her mother died of colon cancer few years ago. She writes about stories, research news and advances in treatment related to colon cancer.

Prostate cancer blog: Prostate cancer is the most common cancer among American men. American Cancer Society estimates that over 230,000 new cases of prostate cancer occur in the United state every year. This important blog about prostate cancer is run by Mark and other bloggers. This blog brings news, stories, and other personal observations related to prostate cancer.

Medicineworld.org publishes a diabetes watch blog and this blog is run by JoAnn other bloggers. This diabetes watch blog brings you the latest in the field of diabetes. This includes personal stories, advances in diagnosis and treatment, and other observations about diabetes. Improving awareness about diabetes is an important mission of this group.

Janet      

Nov 16, 2005

Diabetics Have Higher Risk Of Colorectal Cancer

Diabetics Have Higher Risk Of Colorectal Cancer
A new study confirms that patients with diabetes are significantly more likely to have colon cancer than individuals without diabetes. Researchers at the Medical University of South Carolina reported results from a large cross-sectional analysis assessing the risk of colon cancer among patients with diabetes at the 70th Annual Scientific Meeting of the American College of Gastroenterology.
Researchers analyzed data from a comprehensive nationally representative sample of patients using the 1997-2003 National Health Interview Survey. Of the 226,953 patients in the study, 5.9 percent had a history of diabetes. Researchers controlled for age, race, gender, obesity, alcohol use, tobacco use, and physical activity. Adjusting for potentially confounding factors, researchers found that people with diabetes were 1.4 times more likely to have colon cancer as individuals without diabetes.
"This work is important because it suggests that people with diabetes may be at higher risk of colon cancer. Until we know for sure, diabetics should pay particular attention to their doctor's recommendations for colorectal screening," said Donald Garrow, M.D. one of the investigators.


Sue      Permalink

Nov 14, 2005

Coffee May Protect Against Colon Cancer

Coffee May Protect Against Colon Cancer
I was drinking my evening cup of coffee and was thinking about the topic that I wanted to write today. When I read about this coffee news, I decided that this is what I am going to write about today.

This may be the reason for you to take that extra cup of coffee this morning. German researchers say they've found a highly active compound, called methylpyridinium, in coffee that may prevent colon cancer. In studies with animals, this potent antioxidant compound appears to boost the activity of phase II enzymes, which are believed to protect against colon cancer.

This study appear in the Nov. 5 issue of the Journal of Agricultural and Food Chemistry.

Scientists have suspected for years that coffee may offer some cancer protection. This is the first study that's identified a specific, highly active anticancer compound in coffee.

"Until human studies are done, no one knows exactly how much coffee is needed to have a protective effect against colon cancer," study co-leader Thomas Hofman, professor and head of the Institute for Food Chemistry at the University of Munster, says in a prepared statement.

"However, our studies suggest that drinking coffee may offer some protection, especially if it's strong," Hofman says.

He notes that espresso-type coffee contains about two to three times more of the anticancer compound than a medium roast coffee.

Methylpyridinium is found almost exclusively in coffee and coffee products. It's not present in raw coffee beans. It's formed during the roasting process from its chemical precursor, trigonellin. The anticancer compound is present in both caffeinated and decaffeinated coffee and is even found in instant coffee.

Sue      Permalink

Nov 10, 2005

Asbestos Exposure May Increase Risk Of Colorectal Cancer

Asbestos Exposure May Increase Risk Of Colorectal Cancer
Exposure to asbestos is well know to cause mesothelioma, and it has been a long contentious issue if asbestos causes increased risk of colorectal cancer as well. Latest research shows evidence that this may be the case.

Dr. Cullen and associates used data from a cancer prevention trial to investigate the risk of colorectal cancer among nearly 4000 men. These patients were put into two subgroups, one with history of exposure to asbestos and the other without any history of exposure. The researchers have found that men in the asbestos exposed group were 36 percent more likely to develop colorectal cancer compared to those who were not exposed to asbestos.

The researchers have published their finding in the recent issue of American Journal of Epidemiology. Persons who had heavy exposure to asbestos had even higher risk of developing colorectal cancer. People with 21 to 30 years of exposure to asbestos had a 74 percent increased risk of colorectal cancer compared with those with less than 10 years of exposure. The age at first exposure to asbestos was not predictive of the risk of colorectal cancer.

Researchers are recommending aggressive screening for colorectal cancer in those who have exposure to asbestos.

Sue      Permalink

Nov 7, 2005

New Clinical Trial For Metastatic Colorectal Cancer

New Clinical Trial For Metastatic Colorectal Cancer
Pro-Pharmaceuticals is a drug development company commercializing a new generation of anti-cancer treatments using carbohydrate compounds to Glyco-Upgrade the safety and efficacy of FDA-approved chemotherapy drugs by target delivering the drug to cancer cells.

Pro-Pharmaceuticals is going to launch a new clinical trial for patients with advanced stage colorectal cancer using their drug Davanat. The company has announced that, European regulators had approved the trial, which is expected to begin in early 2006.

Pro-Pharmaceuticals will be testing Davanat in combination with another drug in a Phase III clinical trial. Patients who had at least one prior treatment would be eligible for this study. Researchers are hoping the drug prolongs survival by halting the cancer's progression.

Recently, Pro-Pharmaceuticals announced that Davanat showed promise in helping to improve chemotherapy treatments in a separate, early-stage human clinical trial.

Davanat is a proprietary polysaccharide in a Carbosome formation that target delivers chemotherapy drugs to protein receptors (lectins) that are specific to cancer cells.

Contact Information:
Pro-Pharmaceuticals, Inc.
189 Wells Avenue
Newton, MA 02459
Phone(617) 559-0033

Sue      Permalink

Nov 3, 2005

Colorectal Cancer From Tobacco More In Women

Colorectal Cancer From Tobacco More In Women
A new study of gender and risk factors for colorectal cancer reveals that while both tobacco and alcohol increases risk for colorectal cancer, Women who smoke are at a higher risk. Researcher Anna L. Zisman, M.D. of Evanston Northwestern Health Care presented these findings at the 70th Annual Scientific Meeting of the American College of Gastroenterology. Another study presented at ACG about patients undergoing colonoscopy demonstrated that patients over 75 benefit from colorectal cancer screening in detecting cancer and potentially cancerous lesions and experience no more complications from colonoscopy than younger patients.

According to Dr. Zisman, "Understanding interactions between genetic and environmental factors, such as smoking and alcohol use, is critical for colorectal cancer risk stratification, and will help us design effective screening strategies."

Dr. Zisman and her colleagues looked at women's susceptibility compared to men. They found that while age of onset of colorectal cancer was slightly younger in males than females in the non-smoking/non-drinking group, current smokers had a markedly decreased age of presentation for both men and women.

Similarly, alcohol use was associated with an earlier age of diagnosis in males and females. "While both men and women who use tobacco and alcohol are diagnosed with colorectal cancer at an earlier age, the effect of tobacco is significantly greater in women," said Dr. Zisman.

Sue      Permalink

Oct 31, 2005

Olive Oil May Protect Against Colon Cancer

Olive Oil May Protect Against Colon Cancer
Your commonly used olive oil could be your next key weapon against colorectal cancer as per the results of a new study. Researchers from University of Ulster have found that special phenols extracted from olive oil could protect you from colorectal cancer. Researchers are well aware of the protective effects of the Mediterranean diet, which is rich in olive oil, in colon cancer protection. This research sheds light on this well know fact by identifying ways by which olive oil could provide protection and reduce the cancer risk.

Dr Chris IR Gill, one of the researchers, explained: "Because the colon is one of the major cancer sites thought to be protected by olive oil, the UU research team studied the potential anti-cancer effects of virgin olive chemical compounds in cultured cell lines widely used as models for colorectal cancer.

"We found that incubation of one cancer cell line with increasing concentrations of olive oil phenols for 24 hours protected the cells from DNA damage. The effect of olive oil phenols on another cell line after 48 hours of exposure suggested that they 'may exert an anti-promoter effect in the carcinogenesis pathway'.

"While the findings are purely of an experimental nature, they identify mechanisms that support the scientific and medical evidence suggesting an association between olive oil consumption and decreased risk of cancer.

"The research shows that the effect is not only related to the types of fat present in the oil but also the phenolic compounds present. The next stage is to assess the effects in a suitable animal model."

The findings will be published in this month's International Journal of Cancer.

Sue      Permalink

Oct 30, 2005

New Blood Test For Colorectal Cancer

New Blood Test For Colorectal Cancer
Researchers from Johns Hopkins Kimmel Cancer Center in collaboration with Howard Hughes Medical Institute have developed a blood test that may be used to diagnose colorectal cancer. They have published the findings in a Proc. Nat. Acad. Sci., Article (05-07094, 2005).

Researchers used Indivumed's highly standardized biobank to detect elevated levels of mutated adenomatous polyposis coli (APC) gene in the plasma of patients with advanced stage colorectal cancers. This gene mutation was also visible in more than 60 percent of patients with early stage cancers.

Since there is no good test other than invasive colonoscopy to detect early stage colon cancer, this test, which is non-invasive may be used as the foundation for a new type of screening tool for general population who do not have any symptoms related to colorectal cancer.

Sue      Permalink

Oct 25, 2005

CoFactor To Improve Colorectal Cancer Treatment

CoFactor To Improve Colorectal Cancer Treatment


Adventrx Pharmaceuticals, Inc. has presented positive pre-clinical data from a study with CoFactor in a colorectal cancer model at the American Association for Cancer Research (AACR) special conference in cancer research.

The study suggests that CoFactor in combination with 5-fluorouracil (5-FU) and oxaliplatin may be an effective chemotherapeutic regimen against colorectal cancer with higher efficacy and lower toxicity than the equivalent 5-FU, oxaliplatin and leucovorin regimen, informs a company release.

Adventrx's director of preclinical programmes Mark J. Cantwell and chief technical officer Joan M. Robbins, co-authored the study titled, "5,10-methylenetetrahydrofolate enhances anti tumour activity and reduces toxicity of 5-Fluorouracil plus oxaliplatin combination therapy in a colorectal cancer xenograph model."

"While combination therapy with 5-FU, leucovorin and oxaliplatin has shown improved clinical efficacy in treating colorectal cancer compared with 5-FU and leucovorin, optimum efficacy with oxaliplatin combination therapy might not be achieved in this combination due to multiple factors. CoFactor has already demonstrated anti tumour activity with an apparent safer toxicity profile in combination with 5-FU in Phase I and Phase II clinical trials in treatment of metastatic colorectal cancer," said Dr. Cantwell.

Sue      Permalink

Oct 22, 2005

Colorectal Cancer Screening Rates Are Low In The United States

Colorectal Cancer Screening Rates Are Low In The United States
American Cancer Society recommends colorectal cancer screening with flexible sigmoidoscopy or colonoscopy every 5 years for everyone past 50 years of age. Despite this recommendations about half of all patients belonging to this group in the United States do not get colorectal cancer screening.

These findings are from Dr. Jennifer Elston Lafata and colleagues at the Henry Ford Health System in Detroit, who have published their findings from their study in the recent issue of journal 'Cancer'.

These investigators have found that of all patients for whom the screening would be recommended only 54 percent actually received the recommended screening procedure during the study period. The most commonly used screening procedure was colonoscopy, performed on 39.9 percent of screened patients, followed by flexible sigmoidoscopy alone or in combination with fecal occult blood testing.

The researchers however noted an increase in trend towards screening. Between 1999 and 2003, annual screening rates increased by 3.1 percent. The authors suggest that all efforts should be done to improve the colorectal cancer screening rates.

To increase colorectal cancer screening rates, tests that are more acceptable to patients should be developed as per Lafata. "The other part is to make sure that patients who are eligible for screening get a recommendation from their primary care physician" she said.

Sue      Permalink

Oct 18, 2005

Cost effectiveness of CT colonography

Cost effectiveness of  CT colonography
Image courtesy of
University of Chicago
CT colonography is a relatively new imaging technology that can be used to examine the large bowel and rectum where these cancers occur. It is a noninvasive technique that reveals cancer lesions and polyps with nearly the same sensitivity and specificity as colonoscopy, without the risks of bowel perforation.

A study by Heitman and colleagues from Canada compares the costs and effectiveness of CT colonography to the conventional colonoscopy for screening. They found that screening 100 000 patients with CT colonography would cost $2.3 million more (in Canadian dollars) than with colonoscopy, and would avoid 3.8 fatal perforations, but at the same time, this method would lead to 4.1 cancer-related deaths from polyps not seen with CT, which would later become malignant. (Colonoscopy is slightly more sensitive than CT colonography, and could be expected to detect a certain number of polyps that the CT method would miss.)

New technologies are always attractive. Because CT colonography does not physically invade the body, it has even more appeal, it is easier for patients to accept. Its cost, however, is much higher, and its benefit (in terms of years of living that are gained) is only slightly lower than when colonoscopy is used.

Sue      Permalink

Oct 15, 2005

Pre-operative Chemo-radiation Prevents Local Relapse of Rectal Cancer

Pre-operative Chemo-radiation Prevents Local Relapse of Rectal Canceriv chemotherapyPre-operative combination of chemotherapy and radiation may improve outcomes in rectal cancer as per a recent study by German researchers. These researchers working with 26 different hospitals randomly assigned a total of 799 patients with clinical stage II or stage III rectal cancer to receive chemo-radiation either before or after surgery using the drug 5-FU.

Patients in the before-surgery group completed chemoradiation treatment six weeks before surgery. Those in the other group had surgery first, followed by the same chemoradiation regimen, except for a radiation boost delivered to the area where the tumor was removed. Afterwards, patients in both groups received additional treatment with 5-FU.

After a median follow-up period of just under four years, six percent of patients in the before-surgery group had had a local relapse, compared with 13 percent in the after-surgery group. Similar numbers of patients in both groups (36 percent for the before-surgery group; 38 percent for the after-surgery group) had a relapse elsewhere in the body.

Overall survival at five years was 76 percent for the before-surgery group and 74 percent for the after-surgery group. However, this difference was not statistically significant.

Overall, fewer patients in the before-surgery group suffered severe short-term or long-term side effects of treatment, such as diarrhea and the development of narrowings where the bowel was reconnected after removal of the tumor.

Some patients at the start of the trial had tumors that surgeons thought would require the complete removal of the rectum; this, in turn, would require a permanent colostomy (that is, creation of an opening in the wall of the abdomen to allow removal of waste from the body). Among these patients, the before-surgery group was more likely to avoid a colostomy - their rate of bowel reconnection after tumor removal was more than double that of the after-surgery group.

Sue      Permalink

Oct 11, 2005

The story of colonic polyps and colon cancer

The story of colonic polyps and colon cancerAlmost all of the colon cancers develop from benign polyps. These polyps could be easily found by colonoscopy and removed. However, less than half of people 50 and older follow national guidelines for colorectal screenings, according to the Centers for Disease Control and Prevention.

Colorectal polyps are extra bits of tissue, generally shaped like a mushroom or a small dome, growing inside the colon or rectum. Polyps are common finding in the middle aged and elderly. An estimated 30 to 40 percent of adults over the age of 50 develop them. Most are benign and will never develop into cancer. However, one type known as adenomatous polyps, or adenomas, can become cancerous. Genetic changes in these polyps lead to changes in the growth and regulation of their cells, causing them to multiply abnormally. Most adenomas don't become cancerous, but experts say removing them is an excellent way to make sure they don't.

Some researchers say that it takes at least five years for a benign polyp to become cancerous, so frequent screenings are unnecessary. Health experts recommend that you begin having colorectal screening tests at age 50, or sooner if you or a family member has a history of polyps or colon cancer. Your physician can create a screening schedule appropriate for you, based on your individual level of risk.

Many studies have been done to see how a person's eating habits might promote or block the formation of polyps, but specific answers are still lacking. A fiber-rich diet with plenty of vegetables, fruits, whole grains and beans is commonly associated with a lower risk of colon cancer. Yet in one recent large population study, fiber consumption was unconnected to colon cancer occurrence. No randomized clinical trial has shown that increasing people's dietary fiber decreases the first appearance or recurrence of polyps either.

Sue      Permalink

Oct 6, 2005

Mayo clinic researching on colon cancer prevention strategies

Mayo clinic researching on colon cancer prevention strategiesMayo Clinic is participating in a study that is testing a new treatment that may stop polyps from returning.

The study is part of a five-year, $21.6 million colon cancer prevention program grant to the cancer center from the National Cancer Institute, the largest single program grant in the history of the Tucson-based center. Other institutions participating in the three-part program are Baylor University, University of Colorado, MD Anderson Cancer Center in Houston and the Translational Genomics Research Institute (TGen) in Phoenix. Other studies are looking at the epidemiological and lifestyle factors involved in colon cancer.

Mayo's part in the study springs from the preventive advantages of colon screenings.

"Colorectal cancer screenings are different," said Dr. Russell Heigh, the Mayo gastroenterologist in charge of Mayo's participation.

Mammograms and prostate screenings detect existing cancers. But finding a potential cancer before it strikes creates research opportunities in the area of prevention, Heigh said.

Heigh's research will focus on selenium as a possible cancer deterrent.

Other researchers are similarly examining the polyp-preventing traits of aspirin, folic acid and calcium, but the Arizona Cancer Center study is the only one in the country researching selenium.

Selenium is a dietary trace mineral that helps prevent cell damage by the oxidants that cause cancer. It is present in meats such as kidney and liver and in some grains and seeds.

Sue      Permalink


Colorectal cancer
Colorectal cancer is a malignant tumor that arises from the inner wall of the large intestine or rectum. Colorectal cancer is the third commonest cancer diagnosed in the United States. Each year over 100,000 people are diagnosed with colorectal cancer in the United States. Most, of these cancers develop from growths in the colon called polyps. Removal of these polyps can prevent colon cancer.

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