Nov 14, 2005

All About Hitting The Right Target

Choosing the best cancer treatments is often akin to throwing darts at a massive corkboard. You may hit it right or miss it, but as we all know a lot depends upon these uncertainties. How can we improve the odds of hitting correctly?

Researchers have now developed a novel method for selecting the most effective anti-cancer drugs based on the patient's unique tumor activity.

The new approach scans the tumor for evidence of widespread genetic changes that drive the tumor's growth and survival. Rather than simply identifying defective genes, the researchers identified altered "pathways", multiple genes and their proteins that consistently escape normal regulation in tumors.

Cell signaling pathways are a complex hierarchy of genes, and the proteins they produce, that act upon one another in a tag-team relay to ultimately drive a cell's malignant activity, said the researchers from the Duke Institute for Genome Sciences and Policy and the Duke Comprehensive Cancer Center.

"Targeting drugs to deregulated pathways provides a means to avoid giving ineffective drugs to the majority of patients," Joseph Nevins, Ph.D., the senior author of a recent study, published in the recent edition of the journal Nature.

"Instead of prescribing a drug that inhibits the SRC pathway at a tumor that has no SRC deregulation, we can select the right drug for that tumor type." SRC is one of five pathways often deregulated in cancer cells.

Janet      Return to Cancer Blog Main

Do You Read All Of Our Cancer Blogs?

Do you read all of the blogs published by medicineworld.org? Many of our bloggers are busy keeping you updated on the various health related topics. We publish the following blogs at this time.

Cancer blog: I manage the cancer blog with lots of help and support form other bloggers. Through this cancer blog my friends and I try to bring stories of hope for patients with cancer. The cancer blog often republishes important blog posts from other cancer related blogs at Medicineworld.org. If you are searching for a blog that covers wide variety of cancer topics, this may be the one for you.

Breast cancer blog: Breast cancer blog is run by Emily and other bloggers and they bring you the latest stories, news and events that are related to breast cancer. Increasing awareness about breast cancer among women and in the general population is the main goal of this breast cancer blog.

Lung cancer blog: Lung cancer blog is managed by Scott with the help of other bloggers. Through this blog Scott and his friends constantly remind the readers about the dangers of smoking. It's a never-ending struggle against this miserable disease with which a social stigma of smoking is associated.

Colon cancer blog: Colon cancer blog is run by Sue and other bloggers. Sue brings a personal touch to the colon cancer blog since her mother died of colon cancer few years ago. She writes about stories, research news and advances in treatment related to colon cancer.

Prostate cancer blog: Prostate cancer is the most common cancer among American men. American Cancer Society estimates that over 230,000 new cases of prostate cancer occur in the United state every year. This important blog about prostate cancer is run by Mark and other bloggers. This blog brings news, stories, and other personal observations related to prostate cancer.

Medicineworld.org publishes a diabetes watch blog and this blog is run by JoAnn other bloggers. This diabetes watch blog brings you the latest in the field of diabetes. This includes personal stories, advances in diagnosis and treatment, and other observations about diabetes. Improving awareness about diabetes is an important mission of this group.

Heart watch blog: About 13 million Americans suffer from coronary artery disease. Coronary artery disease is the leading cause of death in American men and women amounting a staggering 20 percent of all causes of death. The tremendous responsibility of running a heart blog is entrusted to Daniel. He is creating blog posts with the help and support of other bloggers.

Janet      

Cancer
We do not know the exact cause of many cancers. Many cancers like leukemia have no apparent cause. Some other types of cancers like lung cancers have identifiable causes like smoking in most cases. Lung cancer can occur in those who have never smoked in their life. It is hard to know in these cases what is causing that patients lung cancer. Factors that increase the risk of development of cancer is known as risk factors for cancer. These risk factors may be modifiable like smoking where a person can exert control or un-modifiable factors like age and gender. Smoking can cause cancers of the lungs, mouth, throat, bladder, kidneys and several other organs.